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Publications

  • All-Atom Simulations of Viruses
    Jodi Hadden, Juan R. Perilla
    Current Opinion in Virology , 2018 , Pages: in press
  • Inositol phosphates are assembly co-factors for HIV-1
    Robert Dick, Kaneil Zadrozny, Chaoyi Xu, Florian Schur, Terri Lyddon, Clifton Ricana, Jonathan Wagner, Juan R. Perilla, Barbie Ganser-Pornillos, Marc Johnson, Owen Pornillos, Volker Vogt
    Nature , 2018 , Pages: s41586-018-0396-4
  • All-atom molecular dynamics of the HBV capsid reveals insights into biological function and cryo-EM resolution limits
    Jodi A Hadden, Juan R Perilla, Christopher J Schlicksup, Balasubramanian Venkatakrishnan, Adam Zlotnick, Klaus Schulten
    eLife , 2018 , Pages: e32478
  • Critical Role of the HTLV-1 Capsid N-Terminal Domain for Gag-Gag Interactions and Virus Particle Assembly
    Jessica Martin, Luiza M. Mendonça, Rachel Marusinec , Jennifer Zuczek , Isaac Angert , Ruth Blower, Joachim Mueller, Juan Perilla, Wei Zhang, Louis M Mansky
    Journal of Virology , 2018 , Pages: doi:10.1128/JVI.00333-18
  • Molecular Dynamics Simulations of Protein–Drug Complexes: A Computational Protocol for Investigating the Interactions of Small-Molecule Therapeutics with Biological Targets and Biosensors
    Jodi Hadden, Juan R. Perilla
    In: Computational Drug Discovery and Design , 2018 , Pages: 245-270
  • Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics
    Gongpu Zhao*, Juan R. Perilla*, Ernest Yufenyuy, Xin Meng, Bo Chen, Jiying Ning, Jinwoo Ahn, Angela M. Gronenborn, Klaus Schulten, Christopher Aiken, Peijun Zhang
    Nature , 2013 , 497 , Pages: 643-646
  • Quenching protein dynamics interferes with HIV capsid maturation
    Mingzhang Wang *, Caitlin M. Quinn*, Juan R. Perilla*, Huilan Zhang, Randall Shirra Jr., Guangjin Hou, In-Ja Byeon, Christopher L. Suiter, Sherimay Ablan, Emiko Urano, Theodore J. Nitz, Christopher Aiken, Eric O. Freed, Peijun Zhang, Klaus Schulten, Angela Gronenborn, Tatyana Polenova
    Nature Communications , 2017 , 8 , Pages: 1779
  • CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction
    Frances J. D. Alvarez, Shaoda He, Juan R. Perilla, Sooin Jang, Klaus Schulten, Alan N. Engelman, Sjors H. W. Scheres, Peijun Zhang
    Science Advances , 2017 , 9 , Pages: e1701264
  • CryoEM Structure Refinement by Integrating NMR Chemical Shifts with Molecular Dynamics Simulations
    Juan R. Perilla, Gongpu Zhao, Manman Lu, Jiying Ning, Guangjin Hou, In-Ja L. Byeon, Angela M. Gronenborn, Tatyana Polenova, Peijun Zhang
    Journal of Physical Chemistry B , 2017 , Pages: 10.1021/acs.jpcb.6b13105
  • Physical properties of the HIV-1 capsid from all-atom molecular dynamics simulations
    Juan R. Perilla, Klaus Schulten
    Nature Communications , 2017 , 8 , Pages: 15959
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Perilla Laboratory
Department of Chemistry & Biochemistry
University of Delaware
177 Brown Laboratory
Newark, DE 19716

HIGHLIGHTS

  • Supercomputer Simulations show new target in HIV-1 replication
  • Postdoctoral researcher position
  • The biophysical society spoke with us on the world hepatitis day
  • MD simulations shed light on Hepatitis B virus
  • Lab researchers study the HIV-1 maturation process in the millisecond regime

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Copyright 2017 – Perilla Lab – Department of Chemistry and Biochemistry, University of Delaware